I couldn't go anywhere without Meteor Armor with the Space Gun, I couldn't enter Hardmode without a full set of Molten Armor. In many of my first playthroughs, it was second nature to gain a Gold Broadsword, a Light's Bane/Blood Butcherer, and work my way up to Night's Edge. I wanted to see how using these overlooked items would affect the line of gameplay. One day I decided to start fresh with a new character and world only this time, I was going to focus on summoning items, armor and accessories. Finally, Sorcerers have a wide variety of unique attacks and two different kinds of Spectre headgears, either for additional damage or for healing themselves and teammates. A Ranger keeps its distance from the enemy, firing away with a bullet, arrow or explosive weapon, depending on the Shroomite hat, for high DPS and devastating critical hits.
Pair that with Vampire Knives and a Flask of Ichor and you're set. With a late-game Warrior, it's almost impossible to die due to some insanely high defense, or insanely high damage depending on which Beetle chestplate you wear. I made a number of endgame characters use specific armor, weapon and accessory sets, each pertaining to melee, ranged, or magic bonuses. I've played through Terraria time and time again.